An In - Vitro Study of Transmethylation
نویسندگان
چکیده
Gunter Zveig, Doctor of Philosophy, 1952. (B, S, University of Maryland, 194-A) Title of Thesis: An In-Vitro Study of Transmethylation. Thesis directed by Dr. Fletcher P. Veitch.
منابع مشابه
Biochemical analysis of the role of transmethylation in the methionine dependence of tumor cells.
The effects on methionine metabolism of the substitution of homocysteine for methionine in vitro were investigated in normal and tumor cell lines differing in their ability to utilize homocysteine for growth. The major finding of this study was that methionine-independent (Met-Indep) cell lines had much lower basal transmethylation rates than methionine-dependent (Met-Dep) cell lines. This was ...
متن کاملVitamin B12 and transmethylation in pig, chick, and rat liver homogenates.
The interrelationship of the requirement of choline, methionine, betaine, vitamin B12, and folic acid has been the subject of many recent investigations (2-5). That vitamin Blz functions in the intermediary metabolism of l-carbon units is also well recognized (1, 6-20, 21). However, while there have been several reports concerning the effect of the vitamin in viva and in vitro systems, the prec...
متن کاملVITAMIN Blz AND TRANSMETHYLATION IN PIG, CHICK, AND RAT LIVER HOMOGENATES*
The interrelationship of the requirement of choline, methionine, betaine, vitamin B12, and folic acid has been the subject of many recent investigations (2-5). That vitamin Blz functions in the intermediary metabolism of l-carbon units is also well recognized (1, 6-20, 21). However, while there have been several reports concerning the effect of the vitamin in viva and in vitro systems, the prec...
متن کاملMethionine formation by transmethylation in vitro.
We reported in a previous communication (1) that :guanidoacetic acid is methylated to creatine by rat liver slices in the presence of choline and either homocysteine or homocystine. Choline, homocystine, or homocysteine alone had little or no effect. These observations closed the gap which had existed between the evidence from tissue slice experiments on the one hand (2) and that from experimen...
متن کاملDecreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine.
The ability of S-adenosyl-L-homocysteine (AdoHcy) to inhibit biologic transmethylation reactions in vitro has led us to explore the possibility of pharmacologically manipulating AdoHcy levels in vivo and examining the consequences of these alterations on the transmethylation of some biogenic amines. Swiss-Webster mice were injected intraperitoneally with different doses of adenosine (Ado) and D...
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